You get it as a shot. AIs have been shown to cause arthralgia in up to 46% of patients [10], which can be difficult to treat and can negatively impact quality of life and become potentially persistent with therapy, which makes it obliged to look for effective treatments [5, 11, 12]. And at 12 weeks, the scores were 3.0 and 6.6 () for the TB and placebo groups, respectively, corresponding to 50% improvement in scores compared with baseline for the TB group (). 2017, Article ID 2478565, 8 pages, 2017. https://doi.org/10.1155/2017/2478565, 1Oncology Department, Guang’anmen Hospital, No. Exclusion criteria were the following: (1) patients with endocrine and any other diseases influencing bone metabolism (e.g., hyperthyroidism, hypothyroidism, diabetes, Cushing’s syndrome, chronic liver disease, nephropathy, myeloma, bone tumor, or bone metastasis), (2) use of agents influencing bone metabolism (e.g., glucocorticoid, thyroid hormone, heparin, anticonvulsants, diuretics, or bisphosphonates), except calcium agents, within the past 3 months, (3) contraindications to calcium agents and vitamin D, (4) diagnosis of primary osteoarticular diseases, (5) presence of other primary tumors and severe heart, liver, kidney, and hematopoietic system diseases, and (6) presence of pregnancy, mental illness, or cognitive handicap. Indications. FACT-B was used as the secondary outcome. Send Facebook Twitter reddit EMail Facebook Messenger Web Whatsapp Web Telegram linkedin. Bone stimulators are devices that act as a constant-current source. Due to the unknown mechanism of AIMSS, common treatments mainly aim at relieving the symptoms, including nonsteroidal anti-inflammatory drugs, analgesics, calcitriol agents, vitamin D, and exercise. This trial is registered with ChiCTR-IPR-15007081. In this study, no significant differences were found in serum and FSH change after 12 weeks’ intervention, both in 2 groups, which proved that TB had no impact on AIs’ curative effect on breast cancer, ensuring the safety of TB treating AIMSS. They can cure this illness only by overspending their big bank accounts.". Dr. Wenping Lu, Yifan Li, Zhenhua Zhang, Feifei Cui, Jialing Liu, Yitong Wang, Juling Jiang, and Wenxin Ma approved of the final manuscript. In an enormous setback for wildlife conservation, China announced it will allow hospitals to use tiger bone and rhino horn from captive-bred animals for traditional medicine. Pungent, warm; liver and kidney meridians entered. Anyone has tiger bone wine from China, it must be fake. TB appeared to be effective and safe in the prevention of AIMSS. What is more, the results of MA.17R clinical trials showed that patients received 10 years’ AI treatment could get more benefits than those received 5 years’ therapy on American Society of Clinical Oncology (ASCO), 2016. China’s licensed domestic trade in leopard bone wine and pills is a major driver … Chinese traditional medicine theory considers that kidneys are generating essence and governing bones. How Tiger Balm Works? At baseline, mean pain value was 6.3 and 6.4 () for the TB and placebo groups, respectively. Other 70 participants had finished the intervention, and there were no lost cases. Is there any firm scientific evidence that it actually achieves this? Zhang Li, a doctor practicing traditional medicine at Shanghai's Jinyang Community Medical Center, said the market for tiger and rhino products is driven by rich customers who have a need to show off social status, rather than seeking relief from medical issues. Joint pain and headaches are common side effects. Dr. Wenping Lu, Yifan Li, Feifei Cui, and Zhenhua Zhang participated in the conception and design of this paper. Sign up here as a reviewer to help fast-track new submissions. Traditional Chinese medicine, ... and in 2010 the World Federation of Chinese Medical Societies released a statement urging members not to use tiger bone or … Modern pharmacological research has shown that bionic TB powder has more than 20 kinds of amino-acid and microelements essential to human. In the UK there are shops that sell traditional Chinese medicine and some of these products contain tiger bone. Tiger bones and rhino horns may have a role in traditional Chinese medicine, but critics say that trendy health products with no medical value made from endangered animals are only a status symbol for the wealthy. Joint symptom incidence rate and severity of the pain including average pain, worst pain, pain interference severity, stiffness, and joint symptom interference by M-BPI and VAS were used as the primary outcomes. There are 3,900 tigers and 29,000 rhinos left in wild across Asia and Africa, according to the WWF. Tiger Balm is a product designed to offer instant relief to pain. M-BPI and VAS were used as the primary outcomes. The Effect of Tiger bone Property. The unique blend of herbal ingredients is quickly absorbed into the body to produce a warm, rubbing sensation that relieves pain and swollen muscles. Modern studies have shown prominent anti-inflammatory, analgesic, and antiosteoporotic effects of bionic TB [7]. In this study, we confirmed that postmenopausal women with AI-induced arthralgia demonstrate an improvement in joint pain, stiffness, and functional ability after 12 weeks of TB therapy. The report said the farm considered the tiger carcasses to be worth a fortune and had been waiting for the lift of the tiger products ban. Participants in placebo group were given calcium carbonate tablets (CFDA: H10950029), whose main ingredients are calcium and vitamin D, with recommended dose of 600 mg daily. We also found differences between 2 groups in average pain (2 to 5.6), worst pain (3.9 to 8), pain interference severity (1.9 to 5.3), stiffness (2.4 to 6.9), and joint symptom interference (1.8 to 5.7), all ; similar findings were seen in VAS value (3 to 6.6) at the end of intervention. So we suggested to them taking pills half an hour after meals, and no other adverse events were reported. In traditional Chinese medicine, tiger bones are believed to help cure conditions like rheumatism and arthritis, along with erectile dysfunction. Considering that breast cancer is a hormone-related disease, we also assayed estradiol () and follicle-stimulating hormone (FSH) from patients’ serum samples at the baseline, week 6, and week 12 time point, so as to see if the intervention would influence patients’ hormone levels. However, most patients cannot get satisfying effects [5]. TB (tiger bone) is used to treat bone disease, whose main ingredients are calcium and collagen. Alternative Medicine to Tiger Parts There are close to 11,000 natural, traditional Chinese medicines that can be used to treat ailments and disease. The FACT-B scale has 5 response levels (“not at all” to “very much”), where higher scores reflect better well-being and fewer symptoms. Zhang Hong, a professor of culture at Shanghai's Tongji University, told DW the real reason behind the ban's reversal is lobbying by interest groups. HRQoL measured by FACT-B () was improved. Limbs contracture, palpitation, epilepsy, rectocele, anal fistula, arthritis. It is based on using all natural ingredients including herbs and animal parts. It has been proved that AI is more effective in decreasing the risk of recurrence of breast cancer than Tamoxifen [1], which indicates the important role of AI for adjuvant therapy of postmenopausal breast cancer. Compared with aforesaid trials, this research has a relatively larger sample size, with randomized controlled double-blind design, presenting us a more powerful evidence to support the TB therapy. And group assignments will not be revealed until the entire study is completed. No significant differences were found for the estradiol () and follicle-stimulating hormone (FSH) on 6 weeks or 12 weeks in either group (all ), and there were no significant differences between the two groups in 12 weeks’ time () (Table 4). Besides, calcium to phosphorus ratio of TB makes it suitable for body to absorb, whereas it also contains various organic components, such as collagen, analgesic peptide, bone morphogenetic protein, bone growth factors, and polyose. Tiger is a topical relief cream that is applied directly to the area experiencing pain. By raising the demand for these goods, the farms pose a threat to wild tigers, says author J.A. And more than half of the patients took anastrozole instead of letrozole and exemestane. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Consequences are that AIMSS not only impairs the quality of patients’ life, but also hinders their compliance, which will definitely disrupt further treatments. A Sina Weibo user questioned if there was any scientific proof behind the decision. Background. In traditional Chinese medicine, tiger bones are believed to help cure conditions like rheumatism and arthritis, along with erectile dysfunction. "I believe the decision-makers have a particular disease called 'rich illness.' Traditional Chinese Medicine Bionic Tiger Bone Powder for the Treatment of AI-Associated Musculoskeletal Symptoms, Oncology Department, Guang’anmen Hospital, No. According to professor Zhang, interest groups managed to convince Chinese authorities to decide on such an unpopular policy using political propaganda. A student takes college entrance exams. The objective of this study was to evaluate whether the TB prevented AIMSS in postmenopausal women with ER/PR+ breast cancer. The objective of this study was to evaluate whether the TB prevented AIMSS in postmenopausal women with ER/PR+ breast cancer.Metho… 74.3% participants completed TB therapy experienced at least a 2-point decrease in patient-reported average pain, and 84.1% reported at least a 2-point decrease in stiffness. "Traditional Chinese medicine is just one big lie and the doctors are scammers," an angry Weibo user said in a comment. How Does Tiger Balm Work? Similarly, a 2015 report published by the periodical Southern Weekly said a farm in northeast China's Heilongjiang province was found to be storing the remains of more than 200 tigers in a refrigerator. AIs treat breast cancer mainly by reducing estrogen conversion, thus lowering serum estradiol level [29]. There are still many deficiencies due to our limitations that should be focused on in further study. Dosage and Administrations. They typically consist of one anode, and one or more cathodes. The M-BPI is one of the most widely used instruments to measure pain in cancer patients and has been demonstrated to be a reliable, valid, and responsive measure [8]. osteogenic loading does work through deformation of the bone, or Wolffs law. End-consumers of Tiger Bone Wine & Tiger and Leopard Bones Tiger bone wine is an alcoholic beverage that emerged as a traditional Chinese medicine with alleged health benefits. Besides, more biomarkers should be conducted to evaluate the response to TB therapy such as inflammatory biomarkers. FACT-B measures physical, social/family, emotional, and functional well-being and additional concerns [9]. And 31 patients reported stiffness at baseline in TB group, and 27 of them reported over 2 points’ decrease (87.1%). Yifan Li, Zhenhua Zhang, Feifei Cui, Jialing Liu, Yitong Wang, Juling Jiang, Wenxin Ma, Wenping Lu, "Traditional Chinese Medicine Bionic Tiger Bone Powder for the Treatment of AI-Associated Musculoskeletal Symptoms", Evidence-Based Complementary and Alternative Medicine, vol. Tiger bone crushed and made into a paste has been said to be usable to treat a variety of ailments, including rheumatism and back pain. Based on that, treatments should focus on tonifying the kidney, fortifying the bone, and dispelling the pathogenic factors. Studies show that it works extremely well if force production is sufficient- 4.2x multiple of body weight for the lower extemity bones is he minimum require to elicit the steoblastic activity and inner bone growth. In December 2005, Save the Tiger Fund (STF), a program of the National Fish and Wildlife Foundation, entered into a three-year agreement with the American College of Traditional Chinese Medicine to conduct a global campaign against the use of tiger bone as a medicine and tonic. Actions. “We can’t advertise our tiger wine in Beijing at the moment because the "No one is there because they are ill. At 12 weeks, the mean M-BPI average pain score was 2.0 and 5.6 () for the TB and placebo groups, respectively, corresponding to 50% improvement in scores compared with baseline in the TB group. There are up to an estimated 6,000 tigers in China living in captivity on farms or in zoos and circuses. And, per the National Geographic, tiger bone is used as a protector against "rheumatism and arthritis — and for impotence and flagging libido. You can find more information in our data protection declaration. Rhino horns, which are composed primarily of keratin, a protein found in fingernails and hair, are thought to reduce fever and pains. Physical well-being measured by the FACT-B showed a significant improvement for TB group compared with placebo group (22.23 versus 19.93; ) (Table 3). The mean pain score at baseline, as measured by the M-BPI average pain item on a scale of 0 to 10, was 4.6 and 4.9 for the TB and placebo, respectively (Table 2). A number of small interventional trials investigating vitamin D [13], duloxetine [14], acupuncture [15–17], electroacupuncture [18], glucosamine [19], prednisolone [20], yoga [21], and TCM formulas [22–24] have provided various treatment methods. The endangered animals are bred for luxury items, like tiger bone wine and tigerskin rugs. We modified the inventory by adding “stiffness” (one of the most common symptoms of AIMSS) and “joint symptom interference” to quantify joint stiffness status and evaluate the pain more specifically, on the same 0–10 scale. However, the medical effect of tiger bone has never been determined. Impossible to find at normal pharmacies and on online shopping sites, it's been an open secret that those with connections to zoos, farms and wildlife parks could access tiger skin and bone products. Besides, longer-term studies are necessary to confirm the durability of the response. The outcome comparison between the 2 groups was compared using paired t-test. Our study indicates that TB can play an important role in assisting traditional Chinese herbal medicine in the long-term treatment for AIMSS, in order to alleviate adverse reaction and improve the quality of life much better. Developed by bionic research method, bionic tiger bone powder shows no significant differences with natural tiger bone in ingredients and pharmacologic effects. Dr. Wenping Lu and Yifan Li wrote the manuscript. Generally speaking, osteoporosis medications work by either stopping bone loss or by stopping bone loss and increasing bone density (“antiresorptives”). Most of them were diagnosed I to II pathological stage. Dispel wind and alleviate pain, strengthen bones and relieve convulsion. Yifan Li and Zhenhua Zhang performed data analysis and interpretation. After the announcement, China's Sina Weibo erupted with criticism. One in TB group lost her mother at 3 weeks, so that she had difficulties in scheduling. But Lieberman says, “I know of no evidence for that.” Dr. Wenping Lu, Feifei Cui, Jialing Liu, and Yitong Wang performed provision of study materials or patients. Meanwhile, records in Compendium of Materia Medica say that TB has the function of strengthening bone, expelling wind, and alleviating pain. Besides, compared with other interventions, such as acupuncture, electroacupuncture, and yoga, TB therapy is painless, and it is easier to handle for there is no requirement of doctors’ specific skills. Hence bionic TB powder has taken place of TB and has been widely used in clinical practice to treat osteoporosis and arthrosis. In the last 10 years, 7,100 wild rhinos have been killed by poachers in Africa. Most patients in China moved to TCM (traditional Chinese medicine) for help. In addition, we should try to build multicenters to process the following study. As for HRQoL measured by FACT-B, the improvement of physical well-being had statistical significance; however no same results were seen for other items. 5, Beixiange, Xi Cheng District, Beijing 100053, China. FACT-B was used as the secondary outcome. And 2 participants failed to continue the intervention. Methods. We recruited eligible patients from Guang’anmen Hospital, China Academy of Chinese Medicine, Beijing. The authors declare that they have no competing interests. Patients were asked to complete the following questionnaires at baseline, week 6, and week 12 to evaluate change in pain and functional status. One traditional remedy is a medicinal tiger bone wine, made with ground tiger bones and up to 147 herbs and spices. sailong bone is smaller than tiger bone… its strength is obviously higher than tiger.” Many leaders of the TCM community believe the use of tiger bone is not in the best interests of TCM’s reputation as it strives to become a respected global healthcare choice. Tiger bone products are believed to strenghen bones and joints. 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